International Journal of Ayurveda Research International Journal of Ayurveda Research
  About IJAR | Editors | Search | Current Issue | Archives | Ahead Of Print | Instructions | Online submission | Advertise | Contact Us | Login 
Users Online: 4   Home Print this page Email this page Small font sizeDefault font sizeIncrease font size

CASE REPORT Table of Contents   
Year : 2010  |  Volume : 1  |  Issue : 1  |  Page : 47-48
Subacute thyroiditis following ginger (Zingiber officinale) consumption

Shahed University, Faculty of Medicine, Mustafa Khomeini Hospital, Italia Street, Tehran, Iran

Click here for correspondence address and email

Date of Web Publication 12-Feb-2010


A woman with subacute thyroiditis following ginger consumption is presented. The diagnosis was confirmed by physical examination and laboratory tests, in two distinct episodes. The patient was cured and recommended to refuse ginger consumption.

Keywords: Ginger, subacute thyroiditis, Zingiber officinale

How to cite this article:
Sanavi S, Afshar R. Subacute thyroiditis following ginger (Zingiber officinale) consumption. Int J Ayurveda Res 2010;1:47-8

How to cite this URL:
Sanavi S, Afshar R. Subacute thyroiditis following ginger (Zingiber officinale) consumption. Int J Ayurveda Res [serial online] 2010 [cited 2013 Apr 19];1:47-8. Available from:

   Introduction   Top

Subacute thyroiditis is presumed to be caused by a viral infection or a postviral inflammatory process, and autoimmunity may play a secondary role in this disorder. [1] The resulting inflammation damages thyroid follicles and large amounts of thyroid hormones are released into the circulation, resulting in clinical and biochemical thyrotoxicosis. This state is transient, because new hormone synthesis ceases due to follicular cells damage and inhibition of thyrotropin (TSH) secretion by the increased thyroid hormone concentrations. [2],[3] The thyroid gland is usually slightly or moderately diffusely enlarged, and nearly always tender. Thyrotoxicosis usually subsides in 2-6 weeks, even if the patient is not treated. [4],[5] Subacute thyroiditis is fundamentally a clinical diagnosis and a high erythrocyte sedimentation rate (ESR) is strong confirmatory evidence. Ginger has been used as a heat producer among Iranian population and some studies have shown its effects on metabolism. Thyroid hormones have a regulatory role on metabolism which may be influenced by ginger. To our knowledge this case is a first case that indicates the effects of ginger on thyroid function.

   Case report   Top

A 34-year-old female was referred to a private office, because of sudden onset of severe pain at the back of the mouth and neck radiating to jaw, difficulty in swallowing, hoarse voice, mild fever and palpitation. On physical examination, a red throat without any exudates was observed but cervical lymph nodes enlargement and coryza signs were absent. The thyroid gland was diffusely enlarged (grade Ib or only visible in neck extension) and severely tender [Figure 1]. Patient's temperature was 38 o C and heart rate (HR = 120/min) had disproportionately increased. There was no history of prior goiter, abnormal thyroid function, allergic reactions and recent viral infection. She was not in postpartum period. An interesting finding in her history was ginger powder consumption (1 teaspoonful) with honey (1 tablespoonful) for 10 nights .The thyroid function tests (TFT) revealed thyrotoxicosis. The new TFT indicated the same results. [Table 1] shows useful diagnostic laboratory findings:

Radioactive iodine uptake of thyroid gland was diminished, compatible with the diagnosis of subacute thyroiditis. She had been treated with nonsteroidal antiinflammatory drugs (NSAIDs), propranolol and prednisolone by her physician. Although, she did not consume prescribed drugs regularly, she was relieved after 5 months. One year later, following ginger candy consumption (30 g), she experienced the same previous symptoms in milder form, 24 h after ginger intake. She was referred to us for evaluation, and with the same diagnosis, TFT was requested that revealed thyrotoxicosis [Table 1]. Fortunately, thyrotoxicosis subsided within four weeks only with beta-blocker therapy and patient refused to consume prescribed antiinflammatory drugs, again.

   Discussion   Top

Ginger is commonly used as a cooking spice throughout the world. It is the rhizome of the perennial plant Zingiber officinale in the family Zingiberaceae. The ginger plant has a long history of cultivation, known to have originated in Asia and then spread to other parts of the world. [6] Ginger root is available in various forms including: dried root and powdered ginger. The primary known constitutes of ginger root are gingerol, zingibain, bisabolene, oleoresins, starch, essential oil, mucilage and protein. [7] Ginger contains up to three percent of an essential oil that gives it fragrance. The main constituents are sesquiterpenoids with zingiberene as the main component. Lesser amounts of other sesquiterpenoids (beta-sesquiphellandrene, bisabolene and farnesene) and a small monoterpenoid fraction (beta-phellandrene, cineol and citral) have also been identified. In addition, it is a minor chemical irritant and has sialagogue action, stimulating the production of saliva, which makes it easier to swallow. [8] The medical form of ginger historically was called 'Jamaica ginger' and has been used to treat nausea related to both motion sickness and morning sickness, [7],[9] asthma and bronchitis by loosening and expelling mucus from the lungs, dyspepsia as a carminative, thrombosis as a thromboxane synthetase inhibitor, [7] pain and inflammation due to arthritis, rheumatism and muscle spasm as an antiinflammatory agent [10] and to break fevers by increasing perspiration. [11] The ginger has antioxidative, antidiabetic effects and pressor activity in rats. [12],[13],[7] It is a safe herb and up to now, significant side effects such as thyroiditis have not been reported. Despite its experimental antioxidative and inhibitory effects on metabolic rate, which theoretically may lead to decreased thyroid hormone synthesis, in this report, ginger is presumed to play a role in subacute thyroiditis induction. Inhibitory effect of ginger on metabolic rate and adenylate energy status [14] may damage the integrity of membranes surrounding the thyroid hormones in follicles and eventually release hormones into circulation. Also, subacute thyroiditis may be induced due to an autoimmune process by ginger as an antigen, which changes antigenic properties of thyroid follicular cells. Although, allergic reactions to ginger are generally reported as skin rash, it may promote wider inflammatory responses. It would be interesting to investigate whether this alleged adverse effect has any genetic predisposition. Further research is needed to understand the possible effects of ginger on thyroid gland.

   References   Top

1. Volpe R, Row VV, Ezrin C. Circulating viral and thyroid antibodies in subacute thyroiditis. J Clin Endocrinol Metab 1967;27:1275-84.  Back to cited text no. 1      
2. Becker KL. Principles and practice of endocrinology and metabolism. Vol. 46. Philadelphia: Lippincott W and W; 2001. p. 455-6.  Back to cited text no. 2      
3. Burman KD. Subacute granulomatous thyroiditis. UP To Date 2009,v 17.2. .  Back to cited text no. 3      
4. Lazarus JH. Silent thyroiditis and subacute thyroiditis. The Thyroid: A Fundamental and Clinical Text. In: Braverman LE, Utiger RD, editors. 7th ed. Lippincott-Raven; Philadelphia: 1996. p. 577.  Back to cited text no. 4      
5. Fatourechi V, Aniszewski JP, Fatourechi GZ, Atkinson EJ, Jacobsen SJ. Clinical features and outcome of subacute thyroiditis in an incidence cohort: Olmsted County, Minnesota, study. J Clin Endocrinol Metab 2003;88:2100-5.  Back to cited text no. 5  [PUBMED]  [FULLTEXT]  
6. Zingber officinale information from NPGS/GRIN. Available from: [last retrieved on 2008 Mar 3].  Back to cited text no. 6      
7. Philp RB. Herbal drug interactions and adverse effects. New York: McGraw-Hill; 2004. p. 122-3.  Back to cited text no. 7      
8. McGee H. On Food and Cooking, the science and lore of the kitchen. 2nd ed. New York: Scribner. p. 425-6.  Back to cited text no. 8      
9. Gehrmann B, Koch WJ, Tschirch C, Brinkmann H. Medicinal herbs. New York: The Haworth Herbal Press; 2005. p. 89.  Back to cited text no. 9      
10. Ko R. Adverse reactions to watch for in patients taking herbal remedies. J Med 1999;171:181-6.  Back to cited text no. 10      
11. Ueki S, Miyoshi M, Shido O, Hasegawa J, Watanabe T. Systemic administration of [6]-gingerol, a pungent constituent of ginger, induces hypothermia in rats via an inhibitory effect on metabolic rate. Eur J Pharmacol 2008;584:87-92.  Back to cited text no. 11  [PUBMED]  [FULLTEXT]  
12. Adhikari S, Indira Priyadarsini K, Mukherjee T. Physico-chemical studies on the evaluation of the antioxidant activity of herbal extracts and active principles of some Indian medicinal plants. J Clin Biochem Nutr 2007;40:174-83.  Back to cited text no. 12  [PUBMED]  [FULLTEXT]  
13. Islam MS, Choi H. Comparative effects of dietary ginger (zingber officinale) and garlic (allium sativum) investigated in a type 2 diabetes model of rats. J Med Food 2008;11:152-9.  Back to cited text no. 13  [PUBMED]  [FULLTEXT]  
14. Riewe D, Grosman L, Zauber H, Wucke C, Fernie AR, Geigenberger P. Metabolic and developmental adaptations of growing potato tubers in response to specific manipulations of the adenylate energy status. Plant Physiol 2008;146:1579-98.  Back to cited text no. 14  [PUBMED]  [FULLTEXT]  

Correspondence Address:
Suzan Sanavi
Mustafa Khomeini Hospital, Italia Street, Tehran
Login to access the Email id

PMC citations 2

DOI: 10.4103/0974-7788.59944

PMID: 20532098

Get Permissions


  [Figure 1]

  [Table 1]


    Similar in PUBMED
   Search Pubmed for
  • Sanavi S
  • Afshar R
   Search in Google Scholar for
  • Sanavi S
  • Afshar R
 Related articles
  • Ginger
  • subacute thyroiditis
  • Zingiber officinale
    Email Alert *
    Add to My List *
* Registration required (free)  

    Case report
    Article Figures
    Article Tables

 Article Access Statistics
    Viewed 6726    
    Printed 228    
    Emailed 1    
    PDF Downloaded 684    
    Comments  [Add]    

Recommend this journal